Nuclear pore complex evolution: A trypanosome Mlp analog functions in chromosomal segregation but lacks transcriptional barrier activity

*Department of Pathology, University of Cambridge, Cambridge, UK, †Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, Scotland, DD1 5EH, UK, ‡The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA, §Seattle Biomedical Research Institute, Seattle, Washington, USA and Institute for Systems Biology, Seattle, WA 98109-5234, USA, ||Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan, and ¶Department of Plant Sciences, University of Oxford, South Parks Road, Oxford, OX1 4JP, UK. • Corresponding author: Telephone: +44 (0)751-550-7880, email: [email protected] Running head: Evolution of the NPC and chromatin organisation